The school comedy was one of several NBC shows with uncertain fates after last week's upfronts. "I'm intensely sad to announce that AP Bio will be ending after this season," tweeted creator Mike O'Brien. "This has been my favorite project of my life and that's because of the amazing writers, cast and crew. As most canceled shows probably feel, I think we were just hitting our stride and everyone was still loving the work, so this is very hard. We have 4 left to air and they're 4 of my favorites. Plus 22 others are on Hulu (for now) and http://nbc.com . Please check them out and tell a friend about the show and tell the people who worked on it that they did a good job!"