Grey's Anatomy should kill off Alex Karev even though Justin Chambers has already left the show

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"The only way for Alex to leave the show while still remaining true to his character is for him to meet an untimely demise off screen," says Lauren Thoman. "Similar to how Patrick Dempsey's decision to depart meant that Derek Shepherd had to die, since the only way Derek would permanently leave his wife and kids was in a body bag, Alex is now in a similar situation. Grey's Anatomy has simply done too good a job of growing Alex into a reliable, loyal, stand-up guy for it to be plausible that he'd simply disappear now. As devastating as it would be, both for the characters and the audience, to have to deal with Alex's death, killing him is the only way to write him off the show without getting Chambers back, while still remaining faithful to his character."